Vesicle-associated membrane protein-associated protein A (IPR030229)

Short name: VAPA

Overlapping homologous superfamilies


Family relationships


Vesicle-associated membrane protein-associated protein A (VAPA), also known as VAP33, is an integral membrane protein associated with intracellular vesicles, the endoplasmic reticulum (ER) and microtubules [PMID: 9920726, PMID: 10655491]. In humans, VAPA interacts with proteins involved in regulation of sterol, lipid biosynthesis and trafficking, including the FFAT-motif-containing oxysterol-binding protein (OSBP), the oxysterol-binding protein-related protein (ORP) [PMID: 12023275, PMID: 15212954] and the ceramide transport protein CERT [PMID: 16895911]. VAPA also interacts with proteins that do not have the FFAT motif, including viral proteins [PMID: 14557663], the ER-localised transcription factor ATF6 [PMID: 18263603], and the motor protein Prestin [PMID: 20359505].

GO terms

Biological Process

GO:0070972 protein localization to endoplasmic reticulum

Molecular Function

GO:0033149 FFAT motif binding

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.