Family

Sterol regulatory element-binding protein cleavage-activating protein (IPR030225)

Short name: SCAP

Family relationships

None.

Description

Sterol regulatory element-binding protein cleavage-activating protein (SCAP) is a escort protein required for cholesterol and lipid homeostasis [PMID: 11358865]. It is an endoplasmic reticulum protein with eight transmembrane helices that serves as a cholesterol sensor [PMID: 17428920]. In cholesterol-depleted cells, SCAP transports sterol regulatory element-binding proteins (SREBPs) to the Golgi, where the active fragment of SREBP is liberated by proteases so that it can activate genes for cholesterol synthesis [PMID: 21454655].

GO terms

Biological Process

GO:0032933 SREBP signaling pathway
GO:0008203 cholesterol metabolic process

Molecular Function

GO:0015485 cholesterol binding

Cellular Component

GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER