Sla2 family (IPR030224)

Short name: Sla2_fam

Overlapping homologous superfamilies


Family relationships


The Sla2 family, also known as Sla2p/HIP1/HIP1R family, includes Sla2 from budding yeasts [PMID: 14704157], End4 from fission yeasts [PMID: 15827087], and Huntingtin-interacting protein 1 (HIP1) and HIP1-related (HIP1R) from humans and mice [PMID: 14732715]. They are adaptor proteins that link actin to clathrin and endocytosis in the clathrin-mediated endocytosis (CME) pathway. They contain the ENTH and ANTH (E/ANTH) domain that binds both inositol phospholipids and proteins and contributes to the nucleation and formation of clathrin coats on membranes [PMID: 14657269]. They may bind to actin through their I/LWEQ (talin-like) domain [PMID: 20074057].

GO terms

Biological Process

GO:0006897 endocytosis

Molecular Function

GO:0030276 clathrin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.