Epidermal growth factor receptor kinase substrate 8 (IPR030222)

Short name: EPS8

Overlapping homologous superfamilies


Family relationships



Epidermal growth factor receptor kinase substrate 8 (EPS8) is an signalling adapter that possesses actin binding, bundling, and barbed-end capping activities [PMID: 21835647]. It is critical for dendritic cell migration [PMID: 21835647]. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells [PMID: 24475274]. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) [PMID: 19564905]. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [PMID: 23628062].

GO terms

Biological Process

GO:0051017 actin filament bundle assembly
GO:0051016 barbed-end actin filament capping

Molecular Function

GO:0003779 actin binding
GO:0035591 signaling adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.