Growth factor receptor-bound protein 2 (IPR030219)

Short name: Grb2

Overlapping homologous superfamilies

Family relationships



Growth factor receptor-bound protein 2 (Grb2) is an SH2 and SH3 domain-containing adaptor protein that links receptor tyrosine kinases to Ras signalling [PMID: 1322798]. Grb2 interacts with the cytoplsmic tyrosine kinase ACK1 (activated Cdc42-associated kinase 1) and mediates its interaction with other receptor tyrosine kinases [PMID: 19815557]. ACK1 is implicated in metastatic behaviour, cell spreading and migration, and epidermal growth factor receptor (EGFR) signalling [PMID: 19815557].

The sex muscle abnormal protein 5 from Caenorhabditis elegans is also included in this entry. This is also an SH2 and SH3 domain-containing protein that interacts with receptor tyrosine kinases and is involved in development of the sexual organs, including regulation of vulva induction and sex myoblast migration [PMID: 1372395], regulation of fertility [PMID: 16547100], and oocyte development [PMID: 12169634]. It also has roles in formation of neuromuscular junctions at the larval stage [PMID: 16495308], regulation of fluid homeostasis [PMID: 1372395], cytoskeleton dynamics [PMID: 27780040] and regultion of synaptic levels of nicotinic acetylcholine receptor in the nerve cord [PMID: 15990870].

GO terms

Biological Process

GO:0007265 Ras protein signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.