Nuclear RNA export factor (IPR030217)

Short name: NXF_fam

Overlapping homologous superfamilies


Family relationships


Mex67 is involved in the export of mRNA from the nucleus to the cytoplasm in Saccharomyces cerevisiae [PMID: 9214641]. Vertebrate TAP (also called NXF1 for nuclear RNA export factor 1) is the orthologue of Mex67 [PMID: 9660949]. TAP belongs to a multigene family with conserved modular architecture [PMID: 11073998]. Other members of the family in humans are NXF2, NXF3, and NFX5. Both TAP(NXF1) and NXF2 bind mRNA and display RNA nuclear export activity [PMID: 10668806]. NXF3 also has the ability to export mRNA from the nucleus to the cytoplasm but it uses a different mechanism [PMID: 11545741]. NXF1 and NXF2 are predominantly nuclear, whereas the cytoplasmic presence of NXF3 and NXF5 suggests that they have a different cellular function [PMID: 11073998, PMID: 11566096].

Three functional domains of TAP have been characterised: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain. The RNA-binding domain (RBD) of TAP is located at its amino terminus and is composed of two RNA recognition motifs (RRMs) and one leucine-rich region [PMID: 11724776, PMID: 18364396]. Once bound to mRNA, TAP escorts the messenger ribonucleoprotein (mRNP) to the nuclear pore, where TAP interacts with nucleoporins via the NTF2-like (NTF2L) and UBA domains [PMID: 11583626].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.