Concentrative nucleoside transporter CNT3 (IPR030211)

Short name: CNT3

Overlapping homologous superfamilies


Family relationships


Solute carrier family 28 member 3 (SLC28A3), also known as CNT3, is a sodium-dependent, pyrimidine- and purine-nucleoside transporter [PMID: 11032837, PMID: 16446384, PMID: 15738947]. The ability to substitute H+ for Na+ as one of the coupled cations during the substrate translocation cycle is a characteristic of CNT3 that distinguish it from CNT1 and CNT2 [PMID: 15870078]. It is the only mammalian H+-coupled concentrative nucleoside transporter identified so far, even though its prokaryotic orthologues, such as NupC, do actually transport nucleosides in an H+-dependent manner [PMID: 14668133].

GO terms

Biological Process

GO:1901642 nucleoside transmembrane transport

Molecular Function

GO:0005337 nucleoside transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.