Equilibrative nucleoside transporter 1 (IPR030195)

Short name: ENT1

Overlapping homologous superfamilies


Family relationships


Human Equilibrative, Nitrobenzylthioinosine (NBMPR)-sensitive Nucleoside Transporter ENT1 was the first identified member of the ENT family. ENT1 (also known as solute carrier family 29 member 1, SLC29A1) mediates both influx and efflux of nucleosides across the membrane, including adenosine and many anti-cancer nucleoside drugs [PMID: 8986748, PMID: 11085929]. ENT1 has a predicted topology of 11 transmembrane domains (TMDs) and a large hydrophilic loop in the region between TMD5 and TMD7 [PMID: 11584005]. ENT1 -as ENT2- is localised in plasma membranes and is broadly expressed in tissues [PMID: 12838422, PMID: 23506887].

GO terms

Biological Process

GO:0015858 nucleoside transport

Molecular Function

GO:0005337 nucleoside transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.