Phospholipid transfer protein (IPR030179)

Short name: PLTP

Overlapping homologous superfamilies


Family relationships


Phospholipid transfer protein (PLTP) is a nonspecific lipid transfer protein. Besides phospholipids, PLTP efficiently transfers diacylglycerol, alpha-tocopherol, cerebroside, and lipopolysaccharides [PMID: 6733137]. These transport functions play an important role in lipid and lipoprotein metabolism. Lipoprotein-associated PLTP proteins exist in both active and inactive forms. Active plasma PLTP is associated with apoA-I- containing lipoproteins and inactive one is associated with apoE-containing lipoproteins [PMID: 16520487]. PLTP is considered a promising pharmacological target to treat atherosclerosis [PMID: 22897926].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.