LIM domain-binding protein 1 (IPR030167)

Short name: LDB1

Overlapping homologous superfamilies


Family relationships


LIM domain-binding protein 1 (LDB1) binds to the LIM domain of LIM homeodomain proteins which are transcriptional regulators. LDB1 is a multi-adaptor protein that mediates interactions between different classes of transcription factors and their co-regulators, and hence determine cell fate and differentiation [PMID: 14647207]. In erythroid cells LDB1 is recruited to the beta-globin locus via LMO2 and is required for looping of the beta-globin locus control region (LCR) to the active beta-globin promoter [PMID: 24874989].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0030274 LIM domain binding
GO:0001104 RNA polymerase II transcription cofactor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.