Autoinducer 2 ABC transporter, substrate-binding protein LsrB (IPR030159)

Short name: LsrB

Overlapping homologous superfamilies

Family relationships


Autoinducers are signalling molecules secreted by bacteria to communicate with one another in a process called quorum sensing. Autoinducer 2-binding protein LsrB is part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. It binds AI-2 and delivers it to the LsrC and LsrD permeases [PMID: 11722742].

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043190 ATP-binding cassette (ABC) transporter complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd06302 (PBP1_LsrB_Quorum_Sensing)