Leiomodin-1 (IPR030136)

Short name: LMOD1

Overlapping homologous superfamilies


Family relationships


The Tropomodulin (Tmod) family consist of four Tmods (Tmods 1-4) and three larger variants termed leiomodins (Lmods 1-3), which are expressed in a tissue-specific and developmentally regulated fashion [PMID: 22488942]. Members of the Tmod family are actin filament pointed-end-capping proteins that regulate actin subunit association and dissociation from pointed ends in a tropomyosin-dependent manner [PMID: 10574928].

Leiomodin-1 (LMOD1) is a component of the smooth muscle actin cytoskeleton [PMID: 11350761]. The LMOD1 gene is a SMC (smooth muscle cell)-restricted SRF/MYOCD (serum response factor (SRF)/myocardin (MYOCD) transcriptional switch) target gene [PMID: 22157009].

GO terms

Biological Process

GO:0006936 muscle contraction
GO:0051694 pointed-end actin filament capping

Molecular Function

GO:0005523 tropomyosin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.