I-BAR domain containing protein MIM/ABBA (IPR030127)

Short name: MIM/ABBA

Overlapping homologous superfamilies


Family relationships


This entry represents a subgroup of I-BAR (Bin/amphipysin/Rvs) domain-containing proteins, including MIM (MTSS1) and ABBA (MTSS1-like). BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [PMID: 21743456]. Most I-BAR proteins, including MIM and ABBA, have an additional C-terminal WH2 domain, which binds G-actin [PMID: 12482861, PMID: 12570871, PMID: 18413296].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.