Actin filament-associated protein 1-like 2 (IPR030115)

Short name: AFAP1L2

Overlapping homologous superfamilies


Family relationships


Actin filament-associated protein 1-like 2 (AFAP1L, also known as XB130) belongs to the actin-filament associated protein (AFAP) family of adaptor proteins (including AFAP1, AFAP1L1, and AFAP1L2/XB130). XB130 is an adaptor protein for signal transduction predominantly localised in the cytoplasm, and regulates cell proliferation, survival, and gene expression [PMID: 24995146]. It is a Src kinase substrate [PMID: 17412687] and couples the RET/PTC oncogenic kinase to the PI 3-kinase pathway [PMID: 19060924]. It is involved in growth and survival of different cancer cells [PMID: 22928011].

GO terms

Biological Process

GO:0009966 regulation of signal transduction

Molecular Function

GO:0035591 signaling adaptor activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.