Pathways & interactions
Xin actin-binding repeat-containing protein 2 (IPR030107)
Short name: XIRP2
Overlapping homologous superfamilies
- Xin actin-binding repeat-containing protein 1/2 (IPR030072)
- Xin actin-binding repeat-containing protein 2 (IPR030107)
Proteins in this family contains Xin repeats, which define an actin-binding motif. In humans two Xin-repeat proteins have been identified, XIRP1 and XIRP2. They are expressed during early developmental stages of cardiac and skeletal muscles [PMID: 15454575] and have an important role in cardiac development and function [PMID: 24725425]. They bind to and stabilise F-actin [PMID: 16631741].
This entry represents XIRP2, also known as Xin-beta. In mouse, it initiates the maturation of the intercalated discs (ICDs)during postnatal heart development [PMID: 23261932].
- PTHR22591:SF1 (PTHR22591:SF1)