Xin actin-binding repeat-containing protein 2 (IPR030107)

Short name: XIRP2

Overlapping homologous superfamilies


Family relationships


Proteins in this family contains Xin repeats, which define an actin-binding motif. In humans two Xin-repeat proteins have been identified, XIRP1 and XIRP2. They are expressed during early developmental stages of cardiac and skeletal muscles [PMID: 15454575] and have an important role in cardiac development and function [PMID: 24725425]. They bind to and stabilise F-actin [PMID: 16631741].

This entry represents XIRP2, also known as Xin-beta. In mouse, it initiates the maturation of the intercalated discs (ICDs)during postnatal heart development [PMID: 23261932].

GO terms

Biological Process

GO:0007507 heart development

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.