SWI/SNF complex subunit BRG1 (IPR030100)

Short name: BRG1

Overlapping homologous superfamilies

Family relationships



BRG1 (also know as SMARCA4 or BAF190A) is a core enzymatic subunit of the SWI/SNF complex, an ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling [PMID: 22366787]. In humans BRG1 shares 73% sequence identity with hBRM (human Brahma) and has similar ATPase function in the SWI/SNF complex [PMID: 17274598]. BRG1 contains a conserved ATPase domain and a C-terminal bromodomain that may anchor the entire SWI/SNF complex to promoter nucleosomes [PMID: 17274598]. BRG1 may function as tumour suppressor [PMID: 20418909].

GO terms

Biological Process

GO:0043044 ATP-dependent chromatin remodeling

Molecular Function

GO:0016887 ATPase activity

Cellular Component

GO:0016514 SWI/SNF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.