SWI/SNF-like complex subunit BAF250a (IPR030094)

Short name: BAF250a

Overlapping homologous superfamilies


Family relationships


BAF250a (also known as ARID1a) is part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling. In humans there are two BAF250 isoforms, BAF250a/ARID1a and BAF250b/ARID1b. They are thought to be E3 ubiquitin ligases that target histone H2B [PMID: 20086098]. BAF250a plays key roles in maintaining embryonic stem cell pluripotency and in cardiac development and function [PMID: 22621927, PMID: 18448678]. The BAF250a gene is a tumour suppressor gene that is frequently mutated in ovarian clear cell carcinoma [PMID: 23524907].

GO terms

Biological Process

GO:0006338 chromatin remodeling

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016514 SWI/SNF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.