Pathways & interactions
Melanoma-associated antigen 1 (IPR030093)
Short name: MAGEA1
Overlapping homologous superfamilies
- Melanoma-associated antigen (IPR037445)
- Melanoma-associated antigen 1 (IPR030093)
Melanoma-associated antigen 1 (MAGE1 or MAGEA1) belongs to a family of genes that are active in various types of tumours and silent in normal tissues except in male germ-line cells [PMID: 7927540, PMID: 21933694]. MAGEA1 can act as a transcriptional repressor by binding to the transcriptional regulator SKIP (Ski Interacting Protein). MAGEA1 was also found to actively repress transcription by binding and recruiting histone deacetylase 1 (HDAC1). It could therefore contribute to specific gene expression patterns driving tumour cell growth or spermatogenesis [PMID: 15316101].
- PTHR11736:SF49 (PTHR11736:SF49)