Family

Melanoma-associated antigen 1 (IPR030093)

Short name: MAGEA1

Family relationships

Description

Melanoma-associated antigen 1 (MAGE1 or MAGEA1) belongs to a family of genes that are active in various types of tumours and silent in normal tissues except in male germ-line cells [PMID: 7927540, PMID: 21933694]. MAGEA1 can act as a transcriptional repressor by binding to the transcriptional regulator SKIP (Ski Interacting Protein). MAGEA1 was also found to actively repress transcription by binding and recruiting histone deacetylase 1 (HDAC1). It could therefore contribute to specific gene expression patterns driving tumour cell growth or spermatogenesis [PMID: 15316101].

GO terms

Biological Process

GO:0000122 negative regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0042826 histone deacetylase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER