5'-AMP-activated protein kinase subunit beta-1 (IPR030080)

Short name: AMPK_beta-1

Family relationships



This entry represents the AMP-activated protein kinase (AMPK) beta-1 subunit.

Mammalian AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that regulates whole-body and cellular energy balance in response to energy demand and supply. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3) [PMID: 18855699]. AMPK is activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations [PMID: 21680840]. This kinase complex is found throughout the eukaryotic kingdom, SNF1 kinase complex being the yeast orthologue [PMID: 17712357, PMID: 9759505].

The conserved C-terminal 85-residue sequence of the human beta subunit interacts with both the alpha and gamma subunits, and is necessary for AMPK complex formation [PMID: 15695819]. Beta subunits also contain a conserved N-terminal carbohydrate-binding domain that allows AMPK to function as a glycogen sensor [PMID: 19117544, PMID: 12747837]. The individual AMPK beta subunits display considerable variation in tissue-specific expression and subunit association [PMID: 10544261]. The beta-1 subunit is highly expressed in brain and liver, whereas beta-2 is most highly expressed in skeletal muscle [PMID: 9575201].

GO terms

Biological Process

GO:0045859 regulation of protein kinase activity
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031588 nucleotide-activated protein kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.