Family

SNF1 protein kinase subunit beta-2/beta-3 (IPR030077)

Short name: SIP2/GAL83

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry includes two SNF1 protein kinase complex beta subunits, Sip2 and Gal83 from Saccharomyces cerevisiae. Sip2 is involved in the regulation of ageing [PMID: 10921902, PMID: 12562756], while Gal83 is required for adherence [PMID: 12556493]. This entry also includes 5'-AMP-activated protein kinase subunit beta (a product of the amk2 gene) from Schizosaccharomyces pombe [PMID: 19371376].

The yeast Snf1 kinase is a heterotrimeric enzyme composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [PMID: 9121458]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits [PMID: 17851534]. The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [PMID: 17981722, PMID: 10207618]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.

GO terms

Biological Process

GO:0045859 regulation of protein kinase activity
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031588 nucleotide-activated protein kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER