SNF1 protein kinase subunit beta-2/beta-3 (IPR030077)

Short name: SIP2/GAL83

Overlapping homologous superfamilies


Family relationships



This entry includes two SNF1 protein kinase complex beta subunits, subunit beta-2 (Sip2) and beta-3 (Gal83) from Saccharomyces cerevisiae. Sip2 is involved in the regulation of ageing [PMID: 10921902, PMID: 12562756], while Gal83 is required for adherence [PMID: 12556493]. This entry also includes 5'-AMP-activated protein kinase subunit beta (a product of the amk2 gene) from Schizosaccharomyces pombe [PMID: 19371376].

The yeast Snf1 kinase is a heterotrimeric enzyme composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [PMID: 9121458]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits [PMID: 17851534]. The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [PMID: 17981722, PMID: 10207618]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.

GO terms

Biological Process

GO:0045859 regulation of protein kinase activity
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031588 nucleotide-activated protein kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.