SNF1 protein kinase subunit beta-1 (IPR030073)

Short name: Sip1

Overlapping homologous superfamilies


Family relationships



This entry represents the SNF1 protein kinase complex beta subunit, Sip1, from fungi. In Saccharomyces cerevisiae, the subcellular localisation of SNF1-SIP1 is regulated by cyclic AMP-dependent protein kinase (PKA) [PMID: 14966266].

The yeast Snf1 kinase is a heterotrimeric enzyme composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [PMID: 9121458]. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits [PMID: 17851534]. The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [PMID: 17981722, PMID: 10207618]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources.

GO terms

Biological Process

GO:0006468 protein phosphorylation
GO:0043254 regulation of protein complex assembly
GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031588 nucleotide-activated protein kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.