Pathways & interactions
I-BAR domain containing protein IRTKS (IPR030060)
Short name: IRTKS
Overlapping homologous superfamilies
- I-BAR domain containing protein IRSp53/IRTKS/Pinkbar (IPR027681)
- I-BAR domain containing protein IRTKS (IPR030060)
IRTKS (insulin receptor tyrosine kinase substrate; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 or BAIAP2L1) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. I-BAR domain is a type of the BAR domain, which forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [PMID: 21743456].
IRTKS binds small GTPase Rac rather than Cdc42 [PMID: 17430976]. It serves as an adaptor of the insulin receptor (IR), modulates IR-IRS1-PI3K-AKT signalling via regulating the phosphorylation of IR [PMID: 23896986]. It has been linked to the formation of actin-rich membrane protrusions, called pedestals, during the infection process of enterohemorrhagic Escherichia coli [PMID: 19366662].
- PTHR14206:SF4 (PTHR14206:SF4)