I-BAR domain containing protein IRTKS (IPR030060)

Short name: IRTKS

Overlapping homologous superfamilies


Family relationships


IRTKS (insulin receptor tyrosine kinase substrate; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 or BAIAP2L1) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. I-BAR domain is a type of the BAR domain, which forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [PMID: 21743456].

IRTKS binds small GTPase Rac rather than Cdc42 [PMID: 17430976]. It serves as an adaptor of the insulin receptor (IR), modulates IR-IRS1-PI3K-AKT signalling via regulating the phosphorylation of IR [PMID: 23896986]. It has been linked to the formation of actin-rich membrane protrusions, called pedestals, during the infection process of enterohemorrhagic Escherichia coli [PMID: 19366662].

GO terms

Biological Process

GO:0030833 regulation of actin filament polymerization
GO:0046626 regulation of insulin receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.