Taste receptor type 2 member 4 (IPR030055)

Short name: TAS2R4

Overlapping homologous superfamilies


Family relationships


The taste receptor type 2 (T2R) signal transduction pathway comprises several proteins, including the G-protein alpha-gustducin, the enzyme phospholipase C-beta2 (PLC-beta2), and the transient receptor potential channel-M5 (TRPM5). T2R receptors are implicated in the perception of bitter compounds [PMID: 20022913, PMID: 10761934].

Taste receptor type 2 member 4 (TASR4 or T2R4) is expressed in subsets of taste receptor cells of the tongue, palate epithelium and on airway ciliated epithelium. It is a receptor for denatonium (a very bitter compound) and N(6)-propyl-2-thiouracil (a thiouracil-derived drug used to treat hyperthyroidism) [PMID: 19628819].

GO terms

Biological Process

GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165 signal transduction

Molecular Function

GO:0033038 bitter taste receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.