N-cadherin (IPR030051)

Short name: CDH2

Overlapping homologous superfamilies


Family relationships



N-cadherin (neural-cadherin), also known as cadherin-2 (CDH2), belongs to the cadherin family, whose members are calcium-dependent transmembrane proteins that serve as cell adhesion molecules. N-cadherin is found in a variety of cells, including neural, muscle, and mesenchymal cells. It is involved in the regulation of spine and synaptic plasticity [PMID: 25232112, PMID: 17133224]. N-cadherin has an essential role in several developmental processes in mice [PMID: 23481199] and plays an important role in mediating cardiomyocyte adhesion [PMID: 15662031]. It cooperates with E-cadherin during lens development [PMID: 18996109].

This entry also includes N-cadherin 1 and 2 from Xenopus [PMID: 1893866].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0009966 regulation of signal transduction

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.