Alpha N-catenin (IPR030046)

Short name: CTNNA2

Overlapping homologous superfamilies


Family relationships


Alpha N-catenin (also known as catenin alpha-2, CTNNA2) belongs to the alpha catenin family, whose members are involved in cell adhesion. It is a cadherin-binding protein, widely expressed in the nervous system, and it plays a crucial role in cadherin-mediated cell-cell adhesion. It has diverse roles in the organisation of the central nervous system, but only in limited portions of the brain [PMID: 16691566, PMID: 12089526]. Alpha N-catenin can be recruited to the nucleus upon ZNF639 overexpression [PMID: 16182284]. In mice alpha N-catenin is a key regulator for the stability of synaptic contacts [PMID: 15034585].

GO terms

Biological Process

GO:0048854 brain morphogenesis
GO:0007155 cell adhesion

Molecular Function

GO:0045296 cadherin binding

Cellular Component

GO:0005913 cell-cell adherens junction

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.