Probable C-mannosyltransferase DPY19L2 (IPR030042)

Short name: DPY19L2

Overlapping homologous superfamilies


Family relationships


Dpy-19-like proteins (DPY19L) constitute a novel transmembrane protein family [PMID: 16526957]. This entry represents DPY19L2. DPY19L2 deletion is a major cause of globozoospermia, a condition characterised by round-headed spermatozoa which results in infertility [PMID: 21397063, PMID: 21397064]. DPY19L2 originated from an initial duplication of DPY19L1 on chromosome 7, followed by a recent relocalisation on chromosome 12 in humans, leaving the initial copy on chromosome 7 as a pseudogene (DPY19L2P1) [PMID: 16526957].

GO terms

Biological Process

GO:0007286 spermatid development

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.