Pathways & interactions
Probable C-mannosyltransferase DPY19L2 (IPR030042)
Short name: DPY19L2
Overlapping homologous superfamilies
- Dpy-19/Dpy-19-like (IPR018732)
- Probable C-mannosyltransferase DPY19L2 (IPR030042)
Dpy-19-like proteins (DPY19L) constitute a novel transmembrane protein family [PMID: 16526957]. This entry represents DPY19L2. DPY19L2 deletion is a major cause of globozoospermia, a condition characterised by round-headed spermatozoa which results in infertility [PMID: 21397063, PMID: 21397064]. DPY19L2 originated from an initial duplication of DPY19L1 on chromosome 7, followed by a recent relocalisation on chromosome 12 in humans, leaving the initial copy on chromosome 7 as a pseudogene (DPY19L2P1) [PMID: 16526957].
- PTHR31488:SF6 (PTHR31488:SF6)