Protein Orai-3 (IPR030032)

Short name: Orai-3

Overlapping homologous superfamilies

Family relationships


Orai1 is a pore-forming calcium release-activated calcium (CRAC) channel subunit composed of four transmembrane domains [PMID: 20534587]. Paralogues Orai2 and Orai3 have also been shown to be capable of forming CRAC channels and share Orai1 membrane topology. In these experiments, Orai-1, -2, and -3 channels were similarly inhibited by extracellular Ca2+. Orai3 channels seems to differ from Orai1 and -2 in being relatively resistant to the process of Ca2+ depotentiation [PMID: 17452328]. However, the physiological roles of Orai2 and Orai3 in vivo are currently not well understood [PMID: 23890118].

This entry represents Orai3.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.