Glutamate receptor-interacting protein 1 (IPR030026)

Short name: GRIP1

Overlapping homologous superfamilies


Family relationships



Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) [PMID: 24576423]. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [PMID: 11931740, PMID: 16055064]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 [PMID: 24576423].

This entry represent GRIP1. The interaction between GRIP1 and 14-3-3 proteins is essential for the function of GRIP1 as an adaptor protein in dendritic cargo trafficking [PMID: 24576423].

GO terms

Biological Process

GO:0016358 dendrite development

Molecular Function

GO:0030159 receptor signaling complex scaffold activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.