Neuroligin 4 (IPR030025)

Short name: NLGN4

Overlapping homologous superfamilies

Family relationships


Neuroligin 4 (NLGN4) belongs to the neuroligins (NLGNs) family, whose members interact with the neurexin family members and are involved in the modulation of synaptic transmission [PMID: 24860089]. This entry includes the X-linked and Y-linked NLGN4 from humans. In mice NLGN4 is localised to glycinergic postsynapses and regulates inhibition in the retina [PMID: 21282647]. NLGN4 is also found at excitatory (glutamatergic) synapses [PMID: 15620359, PMID: 25149987].

X-linked NLGN4 has been linked to Autism [PMID: 12669065] and Asperger syndrome [PMID: 14963808].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0050808 synapse organization

Molecular Function

GO:0042043 neurexin family protein binding

Cellular Component

GO:0005887 integral component of plasma membrane
GO:0045202 synapse

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.