Neuroligin-3 (IPR030024)

Short name: NLGN3

Overlapping homologous superfamilies

Family relationships


Neuroligin-3 (NLGN3) belongs to the neuroligins (NLGNs) family, whose members interact with the neurexin family members and are involved in the modulation of synaptic transmission [PMID: 24860089]. NLGN3 is a neuronal adhesion protein at both inhibitory GABAergic synapses and excitatory (glutamatergic) synapses [PMID: 17897391]. Mutations in neuroligin 3 genes have been found in autism [PMID: 25149987].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0050804 modulation of chemical synaptic transmission
GO:0050808 synapse organization

Molecular Function

GO:0042043 neurexin family protein binding

Cellular Component

GO:0005887 integral component of plasma membrane
GO:0045202 synapse

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.