Villin (IPR030007)

Short name: Villin

Overlapping homologous superfamilies


Family relationships


Villin belongs to the villin/gelsolin family, whose members are actin-modulating proteins that sever F-actin, cap the barbed ends of actin filaments preventing monomer exchange, and promote the nucleation step of actin polymerisation [PMID: 17182858]. Villin is involved in actin remodelling necessary for many cellular processes requiring the actin cytoskeleton plasticity [PMID: 12181160, PMID: 18307996].

This entry represents villin from vertebrates.

GO terms

Biological Process

GO:0051693 actin filament capping
GO:0051014 actin filament severing
GO:0045010 actin nucleation

Molecular Function

GO:0051015 actin filament binding
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.