Gelsolin (IPR030004)

Short name: Gelsolin

Overlapping homologous superfamilies


Family relationships


Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [PMID: 14527663, PMID: 3023087]. It can be regulated by Ca2+ and phosphoinositides [PMID: 3027569]. The interaction between gelsolin and tropomyosin modulates actin dynamics [PMID: 23844991]. Gelsolin also plays a role in ciliogenesis [PMID: 20393563]. The structure of gelsolin has been solved [PMID: 9288746].

In humans there are two forms of gelsolin generated by alternative splicing. One is the cytosolic form that has a role in the regulation of the actin cytoskelton [PMID: 6325429], the other is the secreted form that may be part of the actin scavenging system in the bloodstream [PMID: 1314333]. Mutations in gelsolin gene cause familial amyloidosis of Finnish type (FAF) [PMID: 15336957].

GO terms

Biological Process

GO:0051014 actin filament severing
GO:0045010 actin nucleation
GO:0051016 barbed-end actin filament capping

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.