Otoferlin (IPR029996)

Short name: Otoferlin

Overlapping homologous superfamilies


Family relationships


Otoferlin is a multi-C2 domain protein that belongs to the ferlin family, whose members are implicated in membrane-membrane fusion events [PMID: 22959777]. It is required for synaptic transmission at the inner hair cell ribbon synapse [PMID: 22959777, PMID: 18287496].

GO terms

Biological Process

GO:0016079 synaptic vesicle exocytosis

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.