Phosphatase and actin regulator 3 (IPR029990)

Short name: Phactr3

Overlapping homologous superfamilies


Family relationships



Phosphatase and actin regulator (PHACTR) family members bind to actin and regulate protein phosphatase 1 (PP1) [PMID: 15107502]. PHACTRs are comprised of four family members (Phactr1-4) with distinct expression patterns in the adult brain. They appear to be involved in the regulation of synaptic plasticity via modulating PP1 activity [PMID: 22766235].

Phactr3 (also known as Scapinin) enhances cell spreading and motility by interacting with the actin cytoskeleton [PMID: 19158953]. In mice it is mainly expressed in the brain where it serves as a regulator of neurite outgrowth and neuroplasticity [PMID: 21487013].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding
GO:0008157 protein phosphatase 1 binding
GO:0019888 protein phosphatase regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.