Abnormal spindle-like microcephaly-associated protein (IPR029955)

Short name: ASPM

Overlapping homologous superfamilies


Family relationships



Abnormal spindle-like microcephaly-associated protein (ASPM) is a mitotic spindle protein. In Drosophila it is known as Asp, and it is required to maintain the structure of the centrosomal microtubule organising centre (MTOC) during mitosis [PMID: 10073938]. In humans it is involved in spindle organisation, spindle orientation and cytokinesis [PMID: 21044324]. Mutations in the ASPM gene cause autosomal recessive primary microcephaly (MCPH), which is a rare Mendelian disorder characterised by a congenital deficiency of foetal brain growth, particularly affecting the neocortex [PMID: 21044324].

GO terms

Biological Process

GO:0007051 spindle organization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.