Family

MICAL2 (IPR029939)

Short name: MICAL2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains [PMID: 11827972]. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events [PMID: 23535333]. There is only one MICAL protein found in Drosophila [PMID: 12110185], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates [PMID: 23535333]. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase [PMID: 16275926]. Drosophila MICAL has an NADPH-dependent actin depolymerising activity [PMID: 23535333]. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking [PMID: 21537482].

MICAL2 is a nuclear monooxygenase that promotes depolymerisation of F-actin. Its substrate is the sulfur of a methionine of actin. The FAD domain of MICAL2 could regulate NADPH reduction in the presence of F-actin [PMID: 23927065]. MICAL2 can also regulate SRF (serum response factor) signalling through redox modification of nuclear actin [PMID: 24440334]. Its overexpression has been linked to prostate cancer progression [PMID: 16675569].

GO terms

Biological Process

GO:0030042 actin filament depolymerization
GO:0010735 positive regulation of transcription via serum response element binding

Molecular Function

GO:0043914 NADPH:sulfur oxidoreductase activity
GO:0003779 actin binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER