Uridine-cytidine kinase 2 (IPR029925)

Short name: UCK-2

Overlapping homologous superfamilies

Family relationships


Uridine-cytidine kinase (UCK), also known as uridine kinase, phosphorylates uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) [PMID: 11306702]. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. It also catalyses the phosphorylation of several cytotoxic ribonucleoside analogs that have been investigated for possible use as chemotherapeutic agents for treatment of cancer [PMID: 15130468, PMID: 2910861, PMID: 11306702].

Two UCKs with 70% sequence identity have been reported in human: UCK1 and UCK2 [PMID: 11306702]. This entry represents UCK2. UCK2 is responsible for the majority or uridine and cytidine phosphorylation in cells [PMID: 11306702, PMID: 11494055]. It is overexpressed in some cancer cells and could be used as a target for antitumour and antiviral drugs [PMID: 15735337]. The structure of UCK2 has been solved [PMID: 12876357, PMID: 15735337].

GO terms

Biological Process

GO:0006238 CMP salvage
GO:0044206 UMP salvage

Molecular Function

GO:0019206 nucleoside kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.