Destrin (IPR029924)

Short name: Dstn

Overlapping homologous superfamilies

Family relationships


Destrin (Dstn) is an actin depolymerising factor that maintains a homeostatic ratio of actin in two forms, filamentous actin (F-actin) and globular actin (G-actin). It severs actin filaments (F-actin) and binds to actin monomers (G-actin). Mutations in Destrin gene lead to abnormalities in the structure and function of the cornea and subsequent blindness in mice [PMID: 12700171, PMID: 22419854].

GO terms

Biological Process

GO:0051014 actin filament severing
GO:0030836 positive regulation of actin filament depolymerization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0015629 actin cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.