Uridine-cytidine kinase 1 (IPR029920)

Short name: UCK-1

Overlapping homologous superfamilies

Family relationships


Uridine-cytidine kinase (UCK), also known as uridine kinase, phosphorylates uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) [PMID: 11306702]. UCK is the rate-limiting enzyme in the pyrimidine-nucleotide salvage pathway. It also catalyses the phosphorylation of several cytotoxic ribonucleoside analogs that have been investigated for possible use as chemotherapeutic agents for treatment of cancer [PMID: 15130468, PMID: 2910861, PMID: 11306702].

Two UCKs with 70% sequence identity have been reported in human: UCK1 and UCK2. This entry represents UCK1. The biological role of UCK1 remains unknown, as UCK2 is responsible for the majority or uridine and cytidine phosphorylation in cells [PMID: 11306702, PMID: 11494055].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019206 nucleoside kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.