Pathways & interactions
Protein flightless-1 (IPR029919)
Short name: FliI
Overlapping homologous superfamilies
- Villin/Gelsolin (IPR007122)
- Protein flightless-1 (IPR029919)
Protein flightless-1 (FliI) was first identified in the Drosophila melanogaster [PMID: 8248259]. It belongs to the Villin/Gelsolin family, whose members are actin-modulating proteins that sever F-actin, cap the barbed ends of actin filaments preventing monomer exchange, and promote the nucleation step of actin polymerisation [PMID: 17182858].
This entry represent FliI and its homologues. FliI may serve as a nuclear receptor coactivator [PMID: 14966289] and is involved in embryonic development [PMID: 11971982]. In mouse fibroblasts it caps actin filaments and localises to focal adhesions, which collectively affect focal adhesion maturation [PMID: 22581781].
- PTHR11977:SF55 (PTHR11977:SF55)