Protein flightless-1 (IPR029919)

Short name: FliI

Overlapping homologous superfamilies


Family relationships


Protein flightless-1 (FliI) was first identified in the Drosophila melanogaster [PMID: 8248259]. It belongs to the Villin/Gelsolin family, whose members are actin-modulating proteins that sever F-actin, cap the barbed ends of actin filaments preventing monomer exchange, and promote the nucleation step of actin polymerisation [PMID: 17182858].

This entry represent FliI and its homologues. FliI may serve as a nuclear receptor coactivator [PMID: 14966289] and is involved in embryonic development [PMID: 11971982]. In mouse fibroblasts it caps actin filaments and localises to focal adhesions, which collectively affect focal adhesion maturation [PMID: 22581781].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization
GO:0051014 actin filament severing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.