ISWI family (IPR029915)

Short name: ISWI

Overlapping homologous superfamilies


Family relationships



This entry represent the ISWI family. Its members include ISWI from fruit flies and SMCA1/SMCA5 (SNF2L/SNF2H) from mammals. ISWI is part of the NURF complex, which is an ATP-dependent chromatin remodeling complex that regulates transcription by catalysing nucleosome sliding [PMID: 16264191]. Its structure has been solved [PMID: 14536084].

SMCA5 is a homologue of Drosophila ISWI, which is a major catalytic ATPase subunit of several ISWI-type chromatin remodeling complexes [PMID: 9730600, PMID: 24990377]. Its SLIDE domain can associate with UV-damaged chromatin to specifically promote CSB protein recruitment and to resolve damage-stalled transcription [PMID: 24990377]. It can be recruited to DNA double-strand breaks in a poly(ADP-ribose) polymerase 1 (PARP1)-dependent manner [PMID: 23264744].

GO terms

Biological Process

GO:0043044 ATP-dependent chromatin remodeling

Molecular Function

GO:0016887 ATPase activity

Cellular Component

GO:0016589 NURF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.