Ornithine decarboxylase antizyme 1 (IPR029914)

Short name: ODC-AZ_1

Overlapping homologous superfamilies

Family relationships


Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme of polyamine biosynthesis. Polyamines (putrescine, spermidine, etc) are essential for cell growth. ODC has a very short half-life due to a strong interaction with ODC antizyme 1 (OAZ1) that prevents its homodimerisation and promotes destruction of the monomer units by the 26S proteasome [PMID: 1334232, PMID: 17404802]. In addition to its effects on ODC, OAZ1 also negatively regulates polyamine transport into cells [PMID: 8166639, PMID: 8090747]. By regulating ODC activity, OAZ1 is considered a tumour suppressor gene [PMID: 12873989].

GO terms

Biological Process

GO:0043086 negative regulation of catalytic activity
GO:0006595 polyamine metabolic process

Molecular Function

GO:0008073 ornithine decarboxylase inhibitor activity

Cellular Component

GO:0005829 cytosol

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.