Pathways & interactions
Protein Spire1 (IPR029905)
Short name: Spire1
Overlapping homologous superfamilies
- Protein Spire (IPR029901)
- Protein Spire1 (IPR029905)
This entry represents Spire1, which belongs to the Spire family. It contains a KIND (kinase noncatalytic C-lobe) domain and four actin-binding WH2 (WASP homology 2) domains [PMID: 15674283]. It acts as an actin nucleation factors [PMID: 11747823]. The structure of Spire has been revealed [PMID: 20538977, PMID: 21730168]. Spire1 is involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport [PMID: 21983562].
The mammalian genome encodes two Spir proteins, Spir-1 and Spir-2. In adult tissues, the spir-2 gene shows a rather broad expression pattern, whereas spir-1 is mainly expressed in neuronal cells of the nervous system. Spir-1 may have a role in neural function [PMID: 24345451].
- PTHR21345:SF3 (PTHR21345:SF3)