Protein Spire1 (IPR029905)

Short name: Spire1

Overlapping homologous superfamilies


Family relationships


This entry represents Spire1, which belongs to the Spire family. It contains a KIND (kinase noncatalytic C-lobe) domain and four actin-binding WH2 (WASP homology 2) domains [PMID: 15674283]. It acts as an actin nucleation factors [PMID: 11747823]. The structure of Spire has been revealed [PMID: 20538977, PMID: 21730168]. Spire1 is involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport [PMID: 21983562].

The mammalian genome encodes two Spir proteins, Spir-1 and Spir-2. In adult tissues, the spir-2 gene shows a rather broad expression pattern, whereas spir-1 is mainly expressed in neuronal cells of the nervous system. Spir-1 may have a role in neural function [PMID: 24345451].

GO terms

Biological Process

GO:0045010 actin nucleation
GO:0016192 vesicle-mediated transport

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.