Protein Spire (IPR029901)

Short name: Spire

Overlapping homologous superfamilies


Family relationships


This entry represents the Spire (Spir) family, including vertebrate Spire-1 and Spire-2, Ciona savignyi PEM-5 and Drosophila dSpire. They contain a KIND (kinase noncatalytic C-lobe) domain and four actin-binding WH2 (WASP homology 2) domains [PMID: 15674283]. They act as actin nucleation factors [PMID: 11747823] and are involved in a novel actin-dependent mechanism for long range vesicle transport [PMID: 21983562]. Although Spire proteins are capable of nucleating actin polymerisation in vitro by themselves, they have been found to act in cooperation with members of another family of actin nucleators: the formin subgroup (FMN) of formins [PMID: 23863697]. Spire/formin cooperation is considered to have a major regulatory function in mammalian oocyte maturation [PMID: 21620703]. The structure of Spire has been revealed [PMID: 20538977, PMID: 21730168].

GO terms

Biological Process

GO:0045010 actin nucleation
GO:0016192 vesicle-mediated transport

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.