Kinase non-catalytic C-lobe domain-containing protein 1 (IPR029899)

Short name: KNDC1

Overlapping homologous superfamilies


Family relationships



Kinase noncatalytic C-lobe domain containing 1 (KNDC1), also known as very-KIND, is a brain-specific Ras guanine nucleotide exchange factor (RasGEF) that regulates microtubule-associated protein 2 (MAP2) during dendrite morphogenesis [PMID: 17984326, PMID: 21385318]. It contains two kinase noncatalytic C-lobe domains (KIND1 and KIND2), a RasGEF N-terminal domain (RasN) and a putative RasGEF domain [PMID: 16099729]. The KIND2 domain regulates dendrite complexity via targeting of v-KIND to MAP2 associated with the dendritic microtubule cytoskeleton [PMID: 21385318].

GO terms

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005088 Ras guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.