Profilin-3 (IPR029893)

Short name: PFN3

Overlapping homologous superfamilies

Family relationships


Profilins are a group of small eukaryotic proteins that bind to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). They can also in certain circumstance promote actin polymerisation. Profilins also bind to polyphosphoinositides such as PIP2 [PMID: 11034907]. Other ligands include members of the Ena/VASP and formin families [PMID: 18001770]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. The N-terminal region is thought to be involved in actin binding.

Four Profilins have been identified in mammals, PFN1-4. This entry represents Profilin-3 (PFN3), which is mainly expressed in spermatids [PMID: 11867228, PMID: 19419568]. PFN3 has an actin-binding site, but retains only approximately half of the poly-L-proline binding site [PMID: 19419568].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.