ORM1-like protein 1 (IPR029884)

Short name: ORML1

Overlapping homologous superfamilies


Family relationships


ORM1-like protein 1 (ORML1) belongs to the ORMDL family, whose members may be involved in protein folding in the ER [PMID: 12093374]. It is a negative regulator of sphingolipid synthesis [PMID: 20182505]. ORMDL proteins mediate the feedback regulation of ceramide biosynthesis [PMID: 23066021]. In mammalian cells, ceramide is a proapoptotic signaling sphingolipid.

GO terms

Biological Process

GO:0006672 ceramide metabolic process
GO:0090155 negative regulation of sphingolipid biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.