Rabaptin-5 (IPR029880)

Short name: Rabaptin-5

Overlapping homologous superfamilies


Family relationships

  • Rabaptin (IPR003914)
    • Rabaptin-5 (IPR029880)


Rabaptins interact with the GTP form of the small GTPase Rab5, a potent regulator of endocytic transport [PMID: 8521472]. Two Rabaptins have been identified, Rabaptin-5 and Rabaptin-5beta. Both proteins bind to Rab5 and cooperate in endocytic membrane fusion [PMID: 9524116].

This entry represents Rabaptin-5, which forms a complex with Rabex-5 to activate Rab5 (a small GTPase) and promote early endosomal fusion in endocytosis [PMID: 24957337]. Its structure has been solved [PMID: 15378032].

GO terms

Biological Process

GO:0006897 endocytosis

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

GO:0005768 endosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.