Rho-associated protein kinase 2 (IPR029878)

Short name: ROCK2

Overlapping homologous superfamilies


Family relationships


Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions [PMID: 23601011]. Two ROCK isoforms have been identified: ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [PMID: 23950574, PMID: 19907920].

This entry represents ROCK2. ROCK2 has a predominant role in vascular smooth muscle cell contractility [PMID: 19131646].

GO terms

Biological Process

GO:0007266 Rho protein signal transduction
GO:0010825 positive regulation of centrosome duplication
GO:0032956 regulation of actin cytoskeleton organization
GO:0006939 smooth muscle contraction

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.