Rho-associated protein kinase 2 (IPR029878)
Short name: ROCK2
Overlapping homologous superfamilies
- Rho-associated protein kinase 1/2 (IPR020684)
- Rho-associated protein kinase 2 (IPR029878)
Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions [PMID: 23601011]. Two ROCK isoforms have been identified: ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [PMID: 23950574, PMID: 19907920].
This entry represents ROCK2. ROCK2 has a predominant role in vascular smooth muscle cell contractility [PMID: 19131646].
GO:0004674 protein serine/threonine kinase activity
No terms assigned in this category.
- PTHR22988:SF28 (PTHR22988:SF28)